Osteocalcin intact human

产品名称：Osteocalcin intact human
产    地：Demeditec 
产品货号：DEBT460
产品规格：96 Tests
其它产品：
Osteocalcin mid-tact human Demeditec DEBT480 96 Tests 7942
Osteocalcin rat Demeditec DEBT490 96 Tests 8602
产品说明：
Special remarks: This assay is able to quantify osteocalcin not only in human but also in bovine, canine, and monkey samples.
Osteocalcin, the vitamin K-dependent protein of bone, is a specific product of the osteoblast.  It is distinguished by its small size (5800 daltons) and the presence of gamma-carboxy-glutamic acid (Gla).  In the presence of ionic calcium, the Gla residues allow a specific conformational change in the protein which in turn promotes osteocalcin binding to bone mineral and subsequent accumulation in bone matrix.  While osteocalcin is primarily deposited into the extracellular matrix of bone, a small amount can be detected in the blood.  Circulating osteocalcin is thought to reflect that portion of newly synthesized protein that does not bind to bone but is released directly into the circulation.
Several recent studies suggest that there are various forms of osteocalcin in the circulation and that different antibodies detect different subforms or fragments of osteocalcin.  Many polyclonal antibodies detect both intact and fragmented osteocalcin.  The physiological significance of such osteocalcin fragments is unclear but they may be derived from osteoclastic resorption of matrix, osteoblastic synthesis, systemic catabolism, or all of these.
The assay measures only intact osteocalcin, which is synthesized de novo by the osteoblast, and it eliminates any potential confounding interference by circulating fragments.  The assay is a sandwich EIA which utilizes monoclonal antibodies directed toward the amino- and carboxy- terminal regions of the protein.  It recognizes only intact osteocalcin, requiring the full 49 residue protein for detection.  It is rapid, sensitive and reliable.
上海玉博生物技术有限公司在为生命科学领域提供丰富的产品与信息资源方面处于国内**地位，公司提供的产品涵盖了二十多个国家近五十万种产品，而且产品的数量与信息在不断的增长和更新，公司提供的产品能够使生命科学工作者加快对生物化学，分子生物学，细胞生物学以及蛋白质组学研究的认知，以及分子诊断和临床医学领域的应用。

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