Thyroglobuline (hTG) ELISA

产品名称：Thyroglobuline (hTG) ELISA
产    地：Demeditec 
产品货号：DE7680
产品规格：96 Tests
产品说明：
Special remarks:
Thyroglobulin is an indirect solid phase enzyme immunoassay (ELISA) for the quantitative measurement of thyroglobulin in human serum. The assay is intended for in vitro diagnostic use only as an aid in the diagnosis of various thyroid diseases such as thyroiditis and hyperthyroidism.
Thyroglobulin (hTG) is a multiple glycosylated, water soluble iodoprotein. The molecular weight of approx. 660.000 Dalton is shared by two identical subunits. Thyroglobulin is synthesized in the thyrocytes of the thyroid gland and secreted into the lumen of the thyroid follicles. Iodination of the protein’s tyrosyl residues generates the precursors of the thyroid hormones T3 and T4. Finally the free T3 and free T4 are liberated into circulation, together with small amounts of thyroglobulin. Like for T3 and T4, synthesis and secretion of thyroglobulin is controlled by TSH and TRH. Suppressive medication using the thyroid hormones also leads to lower thyroglobulin serum concentration. Elevated thyroglobulin serum concentrations have been reported in various thyroid diseases, such as
- hyperthyroiditis               
- non-toxic goitre
- thyroiditis                         
- differentiated thyroid carcinoma
Determination of thyroglobulin is a special prognostic value in Graves’ disease patients undergoing therapy. Highly elevated hTG values at the end of a thyrostatic therapy are indicative for an early recidivation, whereas for patients with continuous low thyroglobulin concentrations prognosis tends to continual recovery.
A main application for the thyroglobulin determination is the post surgical monitoring of patients with differentiated thyroid carcinoma. After thyroidectomy, combined with x-ray therapy to destroy remaining thyroid tissue, one can expect an intermediate peak followed by a fast decrease of circulating thyroglobulin concentrations below the detection limit. Each renewed increase of serum thyroglobulin is indicative for residual thyroid tissue, a local recidivation of metastases.
Due to its easy repeatability in the routine monitoring of thyroid carcinoma patients, the determination of thyroglobulin is a valuable non-invasive alternative and supplement to 131I-scintigraphy
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