Histone Ab ELISA

产品名称：Histone Ab ELISA
产    地：Demeditec 
产品货号：DE7670
产品规格：96 Tests
产品说明：
Special remarks:
NAME AND INTENDED USE
Histone  Ab  is  an  indirect  solid  phase  enzyme  immunoassay  (ELISA)  for  the  quantitative measurement of IgG class autoantibodies to histone in human serum or plasma. The assay is intended for in vitro diagnostic use only as an aid in the diagnosis of Systemic Lupus Erythematosus (SLE) or lupus-like disorders.
SUMMARY AND EXPLANATION OF THE TEST
All of the nucleic acids (DNA) of eukaryotic cells is associated  with proteins. The complex structure of DNA and its associated small basic proteins, which are called histones is known as chromatin. Both, The histones comprises about 50 percent of the total mass of eukaryotic chromosomes. The complex of DNA and the histones can be dissociated by treatment of the eukaryotic  chromatin  with  salt  or  diluted  acids.  Five  different  types  of  histones  are known. The are called H1, H2A, H2B, H3 and H4. Their molecular weights range from 11 to 21 kD.
In correlation to their fundamental function in the organisation of chromatin, the structure of all histones in all eukaryotes is highly conserved. They contain a lot of basic amino acid residues which presumably interact with the negative charged groups of DNA. Furthermore they contain apolar amino acid residues which may be important for their interaction among each other.
Antibodies to histones usually produce a homogeneous, rim or speckled pattern of nuclear staining  in  indirect  immunoflourescence.  Antibodies  against  the  histones  dimers  H2A-H2B are observed within 20 to 50 percent in spontaneous systemic Lupus erythematodes and in 50  to  90  percent  in  procainamide  induced  SLE.    Compared  to  other  autoantibodies  anti-histone antibodies are relatively rare in spontaneous SLE. Autoantibodies to histones are not specific for SLE but are found also in drug induced LE and rheumatoid arthritis (RA). In drug induced LE histone antibodies are found in a three times higher incidence than in SLE.
Most  of  the  anti-Histone  antibodies  in  drug  induced  LE  are  of  temporary  character.  They mainly disappear within a few month after treatment with the inducing drug.
Determination of anti-histone antibodies is indicated in:
drug induced Lupus (mainly after treatment with Procainamide, Isoniazide or Hydralazine)
drug induced ANA without clinical SLE symptoms 
spontaneous Systemic Lupus erythematodes        
ANA positive and seropositive rheumatoid arthritis 
ANA positive sclerodermia
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