Thyreoidal Peroxidase Ab (TPO-Ab)

产品名称：Thyreoidal Peroxidase Ab (TPO-Ab)
产    地：Demeditec 
产品货号：DE7580
产品规格：96 Tests
产品说明：
Special remarks:
Thyreoidal Peroxidase Ab (TPO-Ab) is an indirect solid phase enzyme immunoassay (ELISA) for the quantitative measurement of IgG class autoantibodies against thyroid peroxidase (TPO) in human serum or plasma. The assay is intended for in vitro diagnostic use only as an aid in the diagnosis of Hashimoto´s Thyroiditis.
Thyroid disorders are the most prevalent of all autoimmune diseases. Thyroid autoimmune diseases are associated with the occurence of differentiated autoantibodies and are thought to be related to a genetical pre-disposition. These autoantibodies are directed against membrane-located and/or extracellular antigens of the thyroid cells.:
-Thyroglobulin (hTg), a water soluble glycoprotein with a molecular weight of approx. 660.000 Dalton, is the principal constituent of the thyroidal colloid sharing about 75 % of it's mass. Synthesis of the thyroid hormones T3 and T4 is based on the oxidative iodination of thyrosine residues of the thyroglobulin molecule. Within the cell thyroglobulin is trans-ported by the microsomes. Together with the secretion of T3 and T4 also small amounts of hTg are liberated into circulation.
-The microsomal antigen of the thyroid is an integral membrane protein of the microsomes. It has been characterized as the enzyme Thyroid Peroxidase (TPO) with a molecular weight of nearly 110.000 Dalton.
-The TSH-Receptor is a regulatory protein enbedded into the thyroid cell membrane effecting synthesis and release of the thyroid hormones as well as cellular growth.
-The so-called Colloid-Antigen 2 CA2.
Besides these antibodies to functional antigens, antibodies directed against the circulating thyroid hormones T3 und T4 may occur. In Graves' Diseases, an immunogenetic form of hyperthyroidism often additional antibodies occur, which are directed against eye muscle antigens. They cause the endocrine ophalmopathy.
Autoantibodies are found in inflammatory disaeses as well as in thyroid autoimmune disorders. Various symptoms of thyroid diseases, like goiter, thyroid pain, hyperthyroidism and hypothyroidism may be caused by immunogenetic processes and the occurence of organ specific antibodies. This underlines the clinical relevance for autoantibody determination for the assesment of thyroid diseases. Most important autoimmune diseases of the thyroid gland are:          
Hashimoto's Thyroiditis        
Primary Myxedema 
Graves' disease (often associated with endocrine ophtalmopathy)       
and other asymptomatic, for example postpartum thyroiditis.
The occurence of Anti-TG and Anti-TPO autoantibodies at the same time seem to be related to their functional association. Thyrosine amino acid residues of the thyroglobulin molecule, as primary protein for the synthesis of the thyroid hormones T3 and T4, are actively iodinated in association with the thyroid peroxidase (TPO). TSH acts in stimulating synthesis and release of thyroid hormones in close cooperation of all the proteins. This makes the simultaneous appearance of all these antibodies plausible.
Persisting inhibition of the peroxidase activity by specific autoantibodies (Anti-TPO Ab's) causes a decrease in the synthesis of thyroid hormones and thus hypothyroidism. Especially at the end of pregnancy, determination of thyroid antibodies may be a helpful diagnostic tool in the early diagnosis of an onset of post-partum hypothyroidism (Hashimoto's post partum depression).
Hashimoto diseases are often associated with highly elevated titers of thyroid autoantibodies. The concentration of antibodies against thyroglobulin exceeds the titer of Anti-TPO antibodies, whereas in Graves' disease the opposite situation is found, with a stronger elevation of the Anti-TPO antibodies. Additionally, also high concentrations of TSH receptor antibodies is characteristic for both diseases.
上海玉博生物技术有限公司在为生命科学领域提供丰富的产品与信息资源方面处于国内**地位，公司提供的产品涵盖了二十多个国家近五十万种产品，而且产品的数量与信息在不断的增长和更新，公司提供的产品能够使生命科学工作者加快对生物化学，分子生物学，细胞生物学以及蛋白质组学研究的认知，以及分子诊断和临床医学领域的应用。

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