RNP 70 Ab ELISA

产品名称：RNP 70 Ab ELISA
产    地：Demeditec 
产品货号：DE7490
产品规格：96 Tests
产品说明：
Special remarks:
Anti-RNP 70 is an indirect solid phase enzyme immunoassay (ELISA) for the quantitative measurement of IgG class autoantibodies against RNP 70 in human serum or plasma. The assay is intended for in vitro diagnostic use only as an aid in the diagnosis of Systemic Lupus Erythematosus (SLE) and Mixed connective tissue disease (MCTD).
Overlap syndrome is a generic term coined to combine several inflammatory rheumatic diseases characterized by overlapping symptoms of systemic lupus erythematosus (SLE), progressive systemic scleroderma (PSS), Dermato/Polymyositis (DM/PM), rheumatoid arthritis (RA), or Sjögren's syndrome. Mixed connective tissue disease (MCTD) is a serologically well defined overlap syndrome characterized by typical clinical manifestations, distinct autoantibodies specificities and characteristic HLA constellation (i.e. DR2 and DR4). Outstanding clinical manifestation of patients suffering from MCTD is Raynaud's phenomenon with swollen fingers and hands. Additionally, the patients exhibit arthritic complaints. During the course of disease different symptoms of the distinct overlapping connective tissue diseases often emerge in patients suffering from MCTD. However, not all MCTD patients suffer those transitions. Serologically MCTD is characterized by the presence of autoantibodies directed against the 70 kDa protein (also named 60 kDa protein) of the U1-snRNP-Komplex. Up to 100% of MCTD patients manifest high titers of Anti-RNP-70 antibodies. Patients exhibiting only Anti-RNP-70 among the various antinuclear autoantibodies show the classical clinical manifestations of mixed connective tissue disease. Additionally, often SLE typical autoantibodies (e.g. Anti-dsDNA, Anti-Sm, Anti-Histone) come along in the sera of those patients. In these cases classical MCTD will proceed to SLE. The U1-snRNP molecule (its function is splicing of pre-messenger RNA) consists of a uridine rich RNA complexed with the classical RNP antigens, i.e. 70 kDa protein, protein A (33 kDa) and protein C (22 kDa). Also the Sm specific proteins are associated with this RNA. Anti-Sm antibodies are pathognomonic markers for SLE. In the DEMEDITEC Anti-RNP-70 ELISA the wells are exclusively coated with the 70 kDa protein of the U1-snRNP complex. Accordingly, this assays provides the highly specific detection of mainly MCTD associated Anti-RNP-70 autoantibodies.
上海玉博生物技术有限公司在为生命科学领域提供丰富的产品与信息资源方面处于国内**地位，公司提供的产品涵盖了二十多个国家近五十万种产品，而且产品的数量与信息在不断的增长和更新，公司提供的产品能够使生命科学工作者加快对生物化学，分子生物学，细胞生物学以及蛋白质组学研究的认知，以及分子诊断和临床医学领域的应用。

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