Jo-1 Ab ELISA

产品名称：Jo-1 Ab ELISA
产    地：Demeditec 
产品货号：DE7440
产品规格：96 Tests
产品说明：
Special remarks:
Anti-Jo-1 is an indirect solid phase enzyme immunoassay (ELISA) for the quantitative measurement of IgG class autoantibodies against Jo-1 in human serum or plasma. The assay is intended for in vitro diagnostic use only as an aid in the diagnosis of polymyositis and other connective tissue diseases.
Rheumatoid autoimmune diseases are often associated with the occurence of autoantibodies against several nuclear or cytoplasmatic antigens. In patients with Sjögren-Syndrome antibodies against SS-A and SS-B often occur in combination.  The anti SS-A protein passes the placenta and may cause the development of SLE in neonates. Each class of immunoglobulins causes a specific immunofluorescent pattern. Basically immunoflourescence titers correlate with the quantitation of IgG antibodies but the concentrations may vary considerably within each titer. Quantitation of IgG class antibodies extensively correlates with the diseases' activity. This makes it superior to immunofluorescence using Hep2 cells. The IF with Crithidia lucilliae sometimes results in deviating values. Today the best investigated immunoreactive antigens are double-stranded DNA (dsDNA), single stranded DNA (ssDNA), Sm (Smith), sn-RNP (small nuclear ribonucleoprotein particles), the complex RNP/Sm which is stabilized by ribonuleic acid as well as SS-A (Ro) and SS-B (La). The antigen Scl 70, a 70 kD molecular weight protein is associated with scleroderma. In rheumatoid autoimmune diseases various profiles of autoantibodies to these antigens can be detected. In a high incidence they are related to active and inactive systemic Lupus erythrematodes, mixed connective tissue diseases (Sharp Syndrome), rheumatoid arthritis, Sjögren-Syndrome, Scleroderma, photosensitve dermatitis and drug-induced lupus. In Lupus patients typically anti-dsDNA antibodies can be detected. Patients without these antibodies very often show anti-ssDNA antibodies and anti-SS-A and anti-SS-B are present. A strong correlation between antibody concentration and severety of the disease has been observed with higher antibody concentrations in active phases of the disease. Thus quantitation is more informative compared to simple titering by immunoflourescence. Most of these parameters are not specific for just one disease but they occur in various combinations. The pattern of different antibody combinations and their concentration together with the whole clinical picture of the patient are helpful diagnostic tools in the assessment of rheumatoid autoimmune diseases. The following graph gives brief information on the complexity of autoimmune diseases, occuring antibodies. It is not disigned as a diagnostic schedule or program for ongoing diagnostic profiles.
上海玉博生物技术有限公司在为生命科学领域提供丰富的产品与信息资源方面处于国内**地位，公司提供的产品涵盖了二十多个国家近五十万种产品，而且产品的数量与信息在不断的增长和更新，公司提供的产品能够使生命科学工作者加快对生物化学，分子生物学，细胞生物学以及蛋白质组学研究的认知，以及分子诊断和临床医学领域的应用。

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