Prothrombin Screen ELISA

产品名称：Prothrombin Screen ELISA
产    地：Demeditec 
产品货号：DE7230
产品规格：96 Tests
产品说明：
Special remarks:
Anti-Prothrombin Screen is an indirect solid phase enzyme immunoassay (ELISA) for the simultaneous quantitative measurement of IgG, IgM and IgA class autoantibodies against Prothrombin in human serum or plasma. The assay is intended for in vitro diagnostic use only as an aid in the diagnosis of an increased risk of thrombosis in patients with Systemic Lupus Erythematosus (SLE) or lupus-like disorders.
Anti-phospholipid (aPL) antibodies have been associated with venous and arterial thrombosis as well as with recurrent fetal loss. Patients with these symptoms and high aPL antibody levels have been diagnosed as having the anti-phospholipid antibody syndrome (APS). Anti-phospholipid syndrome can occur in patients with systemic lupus erythematosus (SLE) or other autoimmune diseases (secondary anti-phospholipid syndrome) or in patients without underlying autoimmune disease (primary anti-phospholipid syndrome).
In clinical practice anti-cardiolipin antibodies detected by ELISA is one of the most established and standardised tests for diagnosis of the antiphospholipid syndrome. However, the family of aPL antibodies has recently expanded to include a heterogeneous group of antibodies whose specificity is directed against phospholipid binding proteins or their complex with phospholipids.
Among the phospholipid binding proteins, the best studied is ß2-glycoprotein 1 (ß2?GP1). Another phospholipid binding protein, Prothrombin (factor II), exerts a procoagulant activity via a prothrombinase complex, triggering fibrinogen conversion to fibrin.
Autoantibodies can inhibit the formation of the thrombokinase complex.  This complex is formed by the binding of prothrombin to phospholipids on the damaged cell membrane where prothrombin, then, is enzymatically transformed into thrombin. Thrombin, itself, causes blood coagulation. Antibodies directed against coagulation factors, like prothrombin, are pathogenic antibodies, that circulate in the blood stream. They directly inhibit the coagulation factors, and hence prolong the coagulation time. These autoantibodies are also found in association with autoimmune diseases.
The presence of antibodies to prothrombin is associated with thrombosis in patients with SLE and APS. And it was found that high autoantibody levels against prothrombin imply a risk of deep venous thrombosis and pulmonary embolism and could be involved in the development of the thrombotic processes. Furthermore, it was demonstrated that elevated levels of antibodies to prothrombin predict a risk of myocardial infarction.
上海玉博生物技术有限公司在为生命科学领域提供丰富的产品与信息资源方面处于国内**地位，公司提供的产品涵盖了二十多个国家近五十万种产品，而且产品的数量与信息在不断的增长和更新，公司提供的产品能够使生命科学工作者加快对生物化学，分子生物学，细胞生物学以及蛋白质组学研究的认知，以及分子诊断和临床医学领域的应用。

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