CA 125 IRMA

产品名称：CA 125 IRMA
产    地：Demeditec 
产品货号：DE4438
产品规格：96 Tests
产品说明：
Special remarks:
CLINICAL BACKGROUND
Biological activities
CA 125 is a high molecular weight mucin type glycoprotein, originally defined by the Oc 125 monoclonal antibody (Mab) established by Bast et al. Different epitopes, co-expressed with the Oc 125 epitope on the CA 125 antigen, have been used for the development of heterologous assays for determination of the CA 125 antigen.
Clinical applications
Approximately 90% of ovarian cancers are celomic epithelial carcinomas and contain a celomic epithelium-related glycoprotein designated CA 125. CA 125 can be localized in most serous, endometrioid, and clear cell ovarian carcinomas; mucinous tumors express this antigen less frequently. CA 125 is also found in the epithelium of the fallopian tubes, endometrium, and uterine cervix. Elevated CA 125 levels can result from abdominal diseases other than ovarian cancer. Although CA 125 is most consistently elevated in patients with epithelial ovarian cancer, it can be expressed in a number of gynaecologic (eg, endometrium, fallopian tube) and non-gynaecologic (eg, pancreas, breast, colon, lung) cancers. CA 125 levels are frequently elevated with tumor spread beyond the uterus.
PRINCIPLES  OF  THE METHOD
The CA 125-IRMA is a two-step immunoradiometric assay based on coated?tube separation.  Mab1, the capture antibody, is attached to the lower and inner surface of the plastic tube. Add calibrators or samples to the tubes. After incubation, washing removes the occasional excess of antigen. Addition of Mab2, the signal antibody labelled with 125I, will complete the system and trigger the immunological reaction.  After washing, the remaining radioactivity bound to the tube reflects the antigen concentration.
上海玉博生物技术有限公司在为生命科学领域提供丰富的产品与信息资源方面处于国内**地位，公司提供的产品涵盖了二十多个国家近五十万种产品，而且产品的数量与信息在不断的增长和更新，公司提供的产品能够使生命科学工作者加快对生物化学，分子生物学，细胞生物学以及蛋白质组学研究的认知，以及分子诊断和临床医学领域的应用。

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