CA 15-3 IRMA

产品名称：CA 15-3 IRMA
产    地：Demeditec 
产品货号：DE4426
产品规格：96 Tests
产品说明：
Special remarks:
CLINICAL BACKGROUND
Biological activities
The CA 15-3 antigen is a high-molecular-weight mucin glycoprotein termed MUC-1. It has been characterized with monoclonal antibodies developed against purified extracts of a membrane fraction isolated from a human breast carcinoma (clone DF3) and against human milk fat globule membrane (clone 115D8). Other names for the mucin include polymorphic epithelial mucin (PEM), epithelial membrane antigen (MEA) or episalin.
Clinical applications
This marker is most useful in evaluating the effect of treatment for women with advanced breast cancer. Elevated levels of CA15-3 are also associated with cancers of the ovary, lung and prostate, as well as non-cancerous conditions such as benign breast or ovarian disease, endometriosis, pelvic inflammatory disease and hepatitis. Pregnancy and lactation also can raise CA 15-3 levels.
PRINCIPLES OF THE METHOD
The Demeditec CA 15-3-IRMA is a two-step immunoradiometric assay based on coated?tube separation. Mab1, the capture antibody, is attached to the lower and inner surface of the plastic tube. Add calibrators or samples to the tubes. After incubation, washing removes the occasional excess of antigen. Addition of Mab2, the signal antibody labelled with 125I, will complete the system and trigger the immunological reaction. After washing, the remaining radioactivity bound to the tube reflects the antigen concentration.
上海玉博生物技术有限公司在为生命科学领域提供丰富的产品与信息资源方面处于国内**地位，公司提供的产品涵盖了二十多个国家近五十万种产品，而且产品的数量与信息在不断的增长和更新，公司提供的产品能够使生命科学工作者加快对生物化学，分子生物学，细胞生物学以及蛋白质组学研究的认知，以及分子诊断和临床医学领域的应用。
 

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