NSE IRMA

产品名称：NSE IRMA
产    地：Demeditec 
产品货号：DE4411
产品规格：96 Tests
产品说明：
Special remarks:
CLINICAL BACKGROUND
Biological activities
The glycolytic enzyme enolase (2-phospho-D-glycerate hydrolase, EC 4.2.1.11) exists as several dimeric isoenzymes (aa, ab, ag, bb and gg). The gg and ag enolase isoenzymes are also known as neuron- specific enolase (NSE) as they are produced in central and peripheral neurons and malignant tumors of neuroectodermal origin. Elevated serum concentrations of NSE are detected in patients with medullar carcinoma of the thyroid, pancreatic islet cell tumor, pheochromocytoma carcinoid, neuroblastoma and small-cell lung carcinoma (SCLC).
Clinical applications
The diagnosis of lung cancer generally requires medical imaging, endoscopy, intra-operative findings and histology. An important indication for tumor marker determinations in lung cancer is in assessing the efficacy of therapy and post-operative follow-up care. In patients with SCLC, serum levels of NSE reflect the response to chemotherapy.
PRINCIPLES OF THE METHOD
The Demeditec NSE-IRMA is an immunoradiometric assay based on coated-tube separation. Mab1, the capture antibody, is attached to the lower and inner surface of the plastic tube. Calibrators or samples added to the tubes will at first show low affinity for Mab1. Addition of Mab2, the signal antibody labelled with 125I, will complete the system and trigger the immunological reaction. After washing, the remaining radioactivity bound to the tube reflects the antigen concentration.
上海玉博生物技术有限公司在为生命科学领域提供丰富的产品与信息资源方面处于国内**地位，公司提供的产品涵盖了二十多个国家近五十万种产品，而且产品的数量与信息在不断的增长和更新，公司提供的产品能够使生命科学工作者加快对生物化学，分子生物学，细胞生物学以及蛋白质组学研究的认知，以及分子诊断和临床医学领域的应用。

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