Ferritin ELISA

产品名称：Ferritin ELISA
产    地：Demeditec 
产品货号：DE4408
产品规格：96 Tests
产品说明：
Special remarks:
CLINICAL SIGNIFICANCE
Ferritin is a globular protein found mainly in the liver, which can store about 2'250 iron (Fe3+)ions. The ferritin molecule consists of a protein shell (apoferritin) composed of heavy and light subunits, which surrounds a crystalline core containing iron oxide and phosphate.
Ferritin is synthesized in the liver, spleen and numerous other body tissues, with major concentrations found in the liver, spleen, bone marrow, and intestinal mucosa
The ferritin levels measured have a direct correlation with the total amount of iron stored in the body. If ferritin is high there is iron in excess, which would be excreted in the stool. If ferritin is low there is a risk for lack in iron, which sooner or later could lead to anaemia.
In the setting of anaemia, serum ferritin is the most sensitive lab test for iron deficiency anaemia. In contrast, serum ferritin levels are normal or increased in anemia associated with chronic disease. Elevated serum ferritin levels have been observed in acute and chronic liver disease and lymphoid malignancy (leukemia and Hodgkin lymphoma). High serum ferritin levels have also been associated with an elevated risk for myocardial infarction in men. Ferritin is also used as a marker for iron overload disorders, such as haemochromatosis in which the ferritin level may be abnormally raised.
Ferritin is an acute-phase reactant, it is often elevated in the course of disease.
Free iron is toxic to cells, and the body has an elaborate set of protective mechanisms to bind iron in various tissue compartments. Within cells, iron is stored complexed to protein as ferritin or hemosiderin. Apoferritin binds to free ferrous iron and stores it in the ferric state. Under steady state conditions, the serum ferritin level correlates with total body iron stores; thus, the serum ferritin level is the most convenient laboratory test to estimate iron stores.
PRINCIPLE
The Ferritin EIA TEST is based on simultaneous binding of human Ferritin to two monoclonal antibodies, one immobilized on microwell plates and the other conjugates with horseradish peroxidase (HPR).
After incubation the bound/free separation is performed by a simple solid-phase washing, then the TMB-Substrate solution (TMB) is added. After an appropriate time has elapsed for maximum colour development, the enzyme reaction is stopped and the absorbencies are determinated.
The Ferritin concentration in the sample is calculated based on a series of standard.
The colour intensity is proportional to the Ferritin concentration in the sample.
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