PAPP-A IRMA

产品名称：PAPP-A IRMA
产    地：Demeditec 
产品货号：DE42100
产品规格：100 Tests
产品说明：
Special remarks:
Introduction
Pregnancy-associated plasma protein A is a large placenta-derived glycoprotein. The biological function of PAPP-A is not completely known, it has been shown its proteolytic and immuno-regulating action through cleavage of insulin-like growth factor binding protein 4. PAPP-A maternal serum concentration rises during pregnancy. Measurement of PAPP-A, in conjunction with other parameters (free ßhCG concentration, fetal ultrasound, maternal age) can be used in the risk assessment of Down’s syndrome during the first trimester of pregnancy. Mostly, values under 0.5 MOM (multiple of median) are considered pathological, however, isolated PAPP-A data have no diagnostic value by itself.  For screening use, a computerized (parameter-weighted) interpretation of results is necessary with validated software. Each laboratory should determine its own reference (MOM) values.
Principle of method
This technology uses two high affinity monoclonal antibodies in an immunoradiometric assay (IRMA) system. The 125I labelled signal-antibody binds to an epitope of the PAPP-A molecule spatially different from that recognized by the biotin-capture-antibody. The two antibodies react simultaneously with the antigen present in standards or samples, which leads to the formation of a capture antibody - antigen - signal antibody complex, also referred to as a “sandwich”. During 2-hours incubation period with shaking, immuno-complex is immobilized to the reactive surface of streptavidin coated test tubes. Reaction mixture is then discarded, test tubes washed exhaustively, and the radioactivity is measured in a gamma counter. The concentration of antigen is directly proportional to the radioactivity measured in test tubes. By constructing a calibration curve plotting binding values against a series of calibrators containing known amounts of PAPP-A, the unknown concentration of PAPP-A in patient samples can be determined.
上海玉博生物技术有限公司在为生命科学领域提供丰富的产品与信息资源方面处于国内**地位，公司提供的产品涵盖了二十多个国家近五十万种产品，而且产品的数量与信息在不断的增长和更新，公司提供的产品能够使生命科学工作者加快对生物化学，分子生物学，细胞生物学以及蛋白质组学研究的认知，以及分子诊断和临床医学领域的应用。

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