5α-Androstane-3α, 17β-diol-Glucuronide Direct

产品名称：5α-Androstane-3α, 17β-diol-Glucuronide Direct ELISA5α-Androstane-3α, 17β-diol-Glucuronide Direct ELISA
产    地：Demeditec 
产品货号：DE4192
产品规格：96 Tests
产品说明：
Special remarks:
INTENDED USE
For the direct quantitative determination of 3a Diol G by enzyme immunoassay in human serum.
For in vitro diagnostic use only.
PRINCIPLE OF THE TEST
The principle of the following enzyme immunoassay test follows the typical competitive binding scenario.  Competition occurs between an unlabeled antigen (present in standards, control and patient samples) and an enzyme-labelled antigen (conjugate) for a limited number of antibody binding sites on the microwell plate. The washing and decanting procedures remove unbound materials. After the washing step, the enzyme substrate is added.  The enzymatic reaction is terminated by addition of the stopping solution.  The absorbance is measured on a microtiter plate reader.  The intensity of the colour formed is inversely proportional to the concentration of 3α Diol G in the sample.  A set of standards is used to plot a standard curve from which the amount of 3α Diol G in patient samples and controls can be directly read.
CLINICAL APPLICATIONS
5α-Androstane-3α, 17β-diol glucuronide is a C19 steroid and is either abbreviated as 3α Diol G, 5α Diol G or simply, α Diol G.  It is produced mainly as a metabolite of testosterone and dihydrotestosterone (DHT).  It is largely produced in target peripheral tissues such as the skin, especially around hair follicles.  The stimulation by large amounts of 3α Diol G leads to excessive hair formation, notably where hair is not normally present in women.
In recent years the interest in the measurement of this steroid has increased among clinical investigators studying women suffering from idiopathic hirsutism.
Among the steroids known to be precursors for 3α Diol G are dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulphate (DHEAS), dihydrotestosterone (DHT), androstenedione and testosterone.  Only 3α Diol G has been shown to increase with hirsutism and decrease with treatment.  This correlation has also been demonstrated in patients with polycystic ovarian syndrome (PCO).  3α Diol G determinations have therefore proved to be a useful indicator in a variety of ways including monitoring the progress of treatment of idiopathic hirsutism and women with PCO.
Furthermore, diabetic patients (both men and women) under cyclosporine A therapy have shown increased 3α Diol G levels, a side effect resulting in the appearance of hair in previously hairless areas.
上海玉博生物技术有限公司在为生命科学领域提供丰富的产品与信息资源方面处于国内**地位，公司提供的产品涵盖了二十多个国家近五十万种产品，而且产品的数量与信息在不断的增长和更新，公司提供的产品能够使生命科学工作者加快对生物化学，分子生物学，细胞生物学以及蛋白质组学研究的认知，以及分子诊断和临床医学领域的应用。

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