VMA

产品名称：VMA ELISA
产    地：Demeditec 
产品货号：DE1620
产品规格：96 Tests
产品说明：
Special remarks:
1 Name and Intended Use
The VMA ELISA is designed for in vitro quantitative measurement of vanillylmandelic acid (VMA) concentration in patients’ urine.
For in vitro diagnostic use only.
2 Background
Among spectrophotometric procedures the most widely used procedure was developed by Pisano et al (1) measuring vanillin directly at 360 nm. The colorimetric methods in general, however, suffer from interfering compounds and intensive labor requiring a number of manual steps. The use of paper chromatographic methods (2,3) employing diazotized p-nitroanilline and a thin layer chromatographic (TLC) procedure on silica gel (4) were reported for the analysis of extracted VMA but are considered to be of only historical interest. More recently, high performance liquid chromatography (HPLC) procedures are reported using a variety of detectors including ultraviolet light (5-7), amperometirc detection (8-11), and postcolumn reaction (12, 13). These procedures are considered to be a considerable improvement for overall specificity and sensitivity of analysis.
3 Summary and Explanation
Catecholamines include dopamine (found mostly in the central nervous system), norepinephrine (mainly in the sympathetic nervous system) and epinephrine (mainly in the adrenal medulla). They are stored as inactive complex. Released catecholamines, having a short half-life, are taken up by sympathetic nerve endings, or metabolized by the liver and kidney and excreted.
Vanillylmandelic acid (VMA) and 4-hydroxy-3-methoxy-mandelic acid (HMMA) are the end product of both epinephrine and norepinephrine catabolism. Quantitation of the acidic metabolites has long proven to be a reliable diagnostic as well as commonly used follow-up procedure for pheochromocytoma and other catecholamine-, producing tumors (14-16). The prevalence of pheochromocytoma is 0.1% to 0.2% of hypertensive patients (17, 18). Pheochromocytomas have a long record of misdiagnosis due to the metabolic, cardia and gastrointestinal symptoms that can mimic many other diseases. Undetected, or mistreated it can be fatal. However, since this is a surgically curable disease, early diagnosis by demonstration of excess VMA excretion is critically important.
上海玉博生物技术有限公司在为生命科学领域提供丰富的产品与信息资源方面处于国内**地位，公司提供的产品涵盖了二十多个国家近五十万种产品，而且产品的数量与信息在不断的增长和更新，公司提供的产品能够使生命科学工作者加快对生物化学，分子生物学，细胞生物学以及蛋白质组学研究的认知，以及分子诊断和临床医学领域的应用。

产品留言

标题

联系人

联系电话

内容

验证码

点击换一张

注：1.可以使用快捷键Alt+S或Ctrl+Enter发送信息!
2.如有必要,请您留下您的详细联系方式!