Calcitonin

产品名称：Calcitonin IRMA
产    地：Demeditec 
产品货号：DE16100
产品规格：100 Tests
产品说明：
Special remarks:
Introduction
Calcitonin (MW 3.4 kDa) is primarily secreted by the parafollicular C-cells of the thyroid gland. The mature peptide hormone comprises 32 amino acid residues. Calcitonin exerts its biological effect by acting on its target organs: bone, kidney and the gastrointestinal tract. The physiological role of calcitonin in bone metabolism is not fully understood and is still under investigation. It is well established that abnormally elevated levels of calcitonin are characteristic of thyroid C-cell hyperplasia and medullary thyroid carcinoma (MTC). MTC represents 5-10 % of all thyroid cancer and exists in either familial or sporadic form. Calcitonin IRMA is recommended for diagnosis and follow up of MTC and for diagnosis of preclinical cases of the familial forms of MTC.  The circulating concentrations of calcitonin are low, normal values are less then 15 pg/ml, and 10 pg/ml, for males and females, respectively. In the blood the apparent calcitonin-like immunoreactivity is contributed by various calcitonin-related species, including the monomeric, dimeric and polymeric forms, as well as fragments and precursors of the parent hormone.
Principle of method
The technology uses two high affinity monoclonal antibodies in an immunoradiometric assay (IRMA) system. The 125I labelled signal-antibody binds to an epitope of the calcitonin molecule spatially different from that recognized by the biotin-capture-antibody. The two antibodies react simultaneously with the antigen present in standards or samples, which leads to the formation of a capture antibody - antigen - signal antibody complex, also referred to as a “sandwich”. During the overnight incubation period immuno-complex is immobilized to the reactive surface of streptavidin coated test tubes. Reaction mixture is then discarded, test tubes washed exhaustively, and the radioactivity is measured in a gamma counter. The concentration of antigen is directly proportional to the radioactivity measured in test tubes. By constructing a calibration curve plotting binding values against a series of calibrators containing known amount of h calcitonin, the unknown concentration of h calcitonin in patient samples can determined.
上海玉博生物技术有限公司在为生命科学领域提供丰富的产品与信息资源方面处于国内**地位，公司提供的产品涵盖了二十多个国家近五十万种产品，而且产品的数量与信息在不断的增长和更新，公司提供的产品能够使生命科学工作者加快对生物化学，分子生物学，细胞生物学以及蛋白质组学研究的认知，以及分子诊断和临床医学领域的应用。

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