TSH 1h

产品名称：TSH 1h IRMA
产    地：Demeditec
产品货号：DE15100
产品规格：100 Tests
产品说明：
Special remarks: Thyroid-stimulating hormone (TSH) or human thyrotropin is a glycoprotein hormone of approximate molecular weight of 28,000 Da, secreted by thyreotrope cells of the anterior pituitary gland. hTSH is composed of two non covalently bound distinct subunits designated  a and b.The a-subunit is common to the other glycoprotein hormones:  follicle stimulating hormone (hFSH), luteinizing hormone (hLH) and chorionic gonadotropin (hCG). The beta-subunit determines both the biological and immunological  specificity and allows the recognition and the differentiation of hTSH from other glycoprotein hormones by the antibody.
The main function of hTSH is the regulation of synthesis and release  of the thyroid hormones. The secretion and the liberation of hTSH are stimulated by the hypothalamic tripeptide TRH (TSH-Releasing Hormone) and are controlled by serum concentrations of the thyroid hormones:  thyroxine (T4) and triiodthyronine (T3) through a negative feedback mechanism: in the thyreotrope cells, T4 is desiodinated in T3 which directly inhibits hTSH secretion.
When the hypothalamo-hypophyso-thyroid axis is normal, thyroid hormone insufficiency is associated with a response of the thyreoprope cells to TRH, and an increased secretion of hTSH. In contrast, when thyroid  hormones are available in excess, response to TRH is reduced and hTSH  secretion is suppressed. Hypothyroidism  and hyperthyroidism are associated with pathologies if diverse origins of the hypothalamo-hypophyso-thyroid axis, reflected by the concentrations in hTSH, thyroid hormones, and the hTSH response to the exogenous TRH test.
Until now, hTSH measurement was the most sensitive indicator for the diagnosis of primary hypothyroidism with an increased secretion of hTSH and a decrease of thyroid hormone concentrations.
Today, the use of monoclonal antibodies increases the sensitivity of the test
by immunoradiometric sandwich assay and allows a better discrimination
between hyperthyroid and euthyroid population with a decrease in the level.
上海玉博生物技术有限公司在为生命科学领域提供丰富的产品与信息资源方面处于国内**地位，公司提供的产品涵盖了二十多个国家近五十万种产品，而且产品的数量与信息在不断的增长和更新，公司提供的产品能够使生命科学工作者加快对生物化学，分子生物学，细胞生物学以及蛋白质组学研究的认知，以及分子诊断和临床医学领域的应用。

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