Trichostatin A **

产品名称：Trichostatin A
产品货号：Affix  AF3002
产品规格：5 mg
Technical Data
Chemical Name (2E,4E,6R)-7-(4-(Dimethylamino)phenyl)-N-hydroxy-4,6-di methyl-7-oxo-2,4-heptadienamide.
Biological Description Trichostatin A (TSA) is a Selective and potent inhibitor of histone deacetylase (Ki = 3.4 nM). Active in vivo. Potential anti-cancer agent. Induces accelerated dedifferentiation of primordial germ cells (PGCs) into embryonic germ (EG) cells.TSA inhibits the eukaryotic cell cycle during the beginning of the growth stage. TSA can be used to alter gene expression by interfering with the removal of acetyl groups from histones, deacetylases, and HDAC. Therefore altering the ability of DNA transcription factors to access the DNA molecules inside chromatin.
Molecular Weight 302.4
Molecular Formula C17H22N2O3
Solubility Soluble in DMSO and Ethanol (1 mg/ml)
Purity >98 %
Storage instructions Desiccate at -20°C
CAS No. 58880-19-6
References Yoshida et al (1990) Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A. J.Biol.Chem. 265 17174. PMID: 2211619.Wharton et al (2000) Inhibition of mitogenesis in Balb/c-3T3 cells by trichostatin A. J.Biol.Chem. 275 33981. PMID:10945992.Vigushin et al (2001) Trichostatin A is a histone deacetylase inhibitor with potent antitumor activity against breast cancer in vivo. Clin.Cancer Res. 7 971. PMID: 11309348.Durcova-Hills et al (2008) Reprogramming primordial germ cells into pluripotent stem cells. PloS ONE 3 e3531. PMID: 18953407.

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