eFluor 650NC anti-human CD127 **

产品名称：eFluor™ 650NC anti-human CD127 (Interleukin-7 Receptor alpha, IL-7 Receptor alpha, IL-7Ra, IL7Ra) 100 tests
产品货号：eBioscience 95-1278-42
产品规格：100 tests
Anti-Human CD127 eFluor® 650NC
Also known as: Interleukin-7 Receptor alpha, IL-7Ra
Clone: eBioRDR5
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 95-1278
Cat. No. Size
95-1278-41  25 tests 
95-1278-42  100 tests 
Description: The eBioRDR5 monoclonal antibody reacts with human CD127 (Interleukin-7 Receptor α). CD127 complexes with CD132, also known as the common γ chain (γc), to form the multi-functional IL-7 receptor (IL-7R). CD127 is a type I glycoprotein with a molecular weight of 75-80 kDa and is expressed by immature B cells through the early pre-B stage, by thymocytes during several stages of their development, and on most mature T cells, with transient down-regulation upon activation. Binding of IL-7 results in signal transduction which occurs through several tyrosine kinase pathways including the Jak/STAT pathway. IL-7 is indispensible for the development of lymphocytes, and the control of homeostatic proliferation of T-cells in the periphery. In addition, IL-7R signaling is know to be involved in the regulation of T cell receptor (TCR) locus rearrangement in γδ T cells.
Interestingly, recently it has been demonstrated that CD127 expression is down-regulated on CD4+CD25+ regulatory T cells (T regs). While the co-expression of CD4 and CD25 has become widely used as an indicator of T regs, this method of identification may also include cells without suppressive activity. It has clearly been shown that CD4+CD25+ cells that have down-regulated the expression of CD127 are significantly more highly-enriched for the regulatory T population, as defined by expression of the T reg-specific transcription factor Foxp3 and the suppressive activity of these cells, in vitro.
Binding of the eBioRDR5 monoclonal antibody to PBMCs is blocked by pre-incubation of the cells with recombinant human IL-7 (cat. 14-8079).

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