Human Granzyme B ELISPOT Ready-SET-Go! **

产品名称：Human Granzyme B ELISPOT Ready-SET-Go! Set 2 plates
产品货号：eBioscience 88-8399-21
产品规格：2 x 96 tests 
Human Granzyme B ELISPOT Ready-SET-Go!®
Also known as: GrzB, GrB
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 88-8399
Cat. No. Size
88-8399-21  2 x 96 tests 
88-8399-88  10 x 96 tests 
Description: One of the major mechanisms of cell-mediated cytotoxicity involves exocytosis of cytoplasmic granules from the effector toward the target cell. The granules contain a number of proteins, including the pore-forming protein perforin and a family of serine proteases called granzymes, including Granzyme B. Granzyme B is present mainly in the granules of CD8+ CTL and natural killer (NK) cells and mediates the lethal hit that kills virus infected and tumorigenic cells. Measurement of release of Granzyme B in response to the appropriate target is useful for evaluating cell-mediated cytotoxicity. The Granzyme B ELISPOT assay is a valuable non-radioactive alternative to the 51Cr-release killing cell assays for measuring antigen-specific CTL cytotoxicity.
This Granzyme B ELISPOT Ready-SET-Go! reagent set contains the necessary reagents for performing enzyme linked immunosorbent spot (ELISPOT) assays for high resolution frequency analysis of Granzyme B-secreting cells. This ELISPOT reagent set is pre-titrated for optimal spot development.

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