Mouse TSLP Ready-SET-Go!, **

产品名称：Mouse TSLP Ready-SET-Go!, 2 plates
产品货号：eBioscience 88-7490-22
产品规格：2 x 96 tests
Mouse TSLP ELISA Ready-SET-Go!®
Also known as: Thymic Stromal-Derived Lymphopoietin
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 88-7490
Cat. No. Size
88-7490-22  2 x 96 tests w/plates 
88-7490-86  10 x 96 tests w/plates 
88-7490-88  10 x 96 tests 
Description: This Mouse TSLP ELISA Ready-SET-Go! reagent set contains all of the necessary buffers and reagents to perform enzyme-linked immunosorbent assays. The set has been optimized for the accurate and precise measurement of mouse TSLP in serum, plasma, and tissue culture supernatant samples.
TSLP (Thymic Stromal-Derived Lymphopoetin) was first identified in the tissue culture supernatant of a thymic stromal cell line as a growth factor capable of inducing proliferation and differentiation of pre-B cells. It was later found to be closely related to another stromal cytokine, IL-7, with which it shares overlapping functions. Along with its proliferative effects on B cells, TSLP induces dendritic cells to support the differentiation of naïve T cells towards the Th2 lineage and may also be involved in the development of CD4+CD25+ regulatory T cells. The receptor is heterodimeric and shares one subunit, IL-7Rα, with IL-7 and other members of the family, while the TSLPR subunit is unique to TSLP.
TSLP expression can be induced by a variety of inflammatory cytokines and TLR ligands. Expression is regulated by NF-κB and has been detected in epithelial cells, stromal cells, and basophils. Elevated levels of TSLP are associated with asthma and atopic dermatitis, which are both Th2-mediated inflammatory conditions. It is believed that chronic overexpression of TSLP may result in increased sensitivity to allergens, resulting in susceptibility to these conditions.

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