Human LAP Ready-SET-Go! **

产品名称：Human LAP  Ready-SET-Go! ® 20 x 96 tests w/plates
产品货号：eBioscience 88-50390-76
产品规格：20 x 96 tests w/plates
Human LAP ELISA Ready-SET-Go!
Also known as: Latency Associated Peptide, Pro-TGF beta 1, LAP/TGF beta 1
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 88-50390
Cat. No. Size
88-50390-22  2 x 96 tests w/plates 
88-50390-88  10 x 96 tests 
88-50390-86  10 x 96 tests w/plates 
88-50390-77  20 x 96 tests 
88-50390-76  20 x 96 tests w/plates 
Description: This LAP Ready-SET-Go! ELISA Set contains the necessary reagents, standards, buffers and diluents for performing quantitative enzyme-linked immunosorbent assays (ELISA). This ELISA set is specifically engineered for accurate and precise measurement of LAP.
TGF beta is synthesized as a precursor that contains LAP at the N-terminus and mature TGF beta at the C-terminus. Processing and cleavage of the precursor protein between amino acids 278 and 279 results in the formation of LAP dimers and TGF beta dimers that then non-covalently associate with each other to form the small latent TGF beta complex. LAP is secreted and can be found in the extracellular matrix. In addition, LAP can also be expressed on platelets and activated regulatory T cells. It is believed that this surface-expressed LAP is due to the binding of LAP to GARP (LRRC32), which is a transmembrane protein that is also found at high levels on platelets and activated regulatory T cells. Many different cells produce TGF beta and it mediates effects on the proliferation, differentiation and function of many cell types.

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