Human/Non-Human Primate Regulatory T cell Staining **

产品名称：Human/Non-Human Primate Regulatory T cell Staining Kit (containing Foxp3 PCH101) PCH101
产品货号：eBioscience 88-4994-40
产品规格：Kit
Human/Non-Human Primate Regulatory T Cell Staining Kit #2
Also known as: Treg Kit; Foxp3 PCH101 APC; CD4, PE CD25 PE
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 88-4994
Cat. No. Size
88-4994-40  Kit 
Description: Regulatory T cells/Tregs (also known as suppressor T cells) are a specialized subpopulation of T cells that act to suppress immune responses thereby maintaining homeostasis and self tolerance. Intense investigation has tried to determine exclusive protein markers for Tregs. This has been complicated by the identification of four regulatory T cells subsets; natural, anergic, Tr1 and CD8+CD28- suppressor T cells. There are still no cell surface molecules that uniquely distinguish functional regulatory cells from conventional T cells. It has been proposed that the “natural” regulatory T cells originally recognized by their constitutive expression of CD4 and CD25 are further defined by expression of the transcription factor Foxp3. Additionally Foxp3 has also been characterized in CD8+CD28- suppressor T cells.
The Complete Regulatory T Cell Staining Kit contains everything needed to stain the natural Tregs including CD4, CD25 and Foxp3 from human, rhesus, chimpanzee or cynomolgus PBMCs. In baboon, CD25 and Foxp3 can be stained, while CD4 cannot be stained using this kit. Other primate species have not been tested.
This kit has been optimized for staining normal hPBMCs. It is critical to use freshly isolated PBMCs to assure optimal Foxp3 staining.
Not included:
Isotype controls for anti-CD4 (mouse IgG1, cat. 11-4714) and anti-CD25 (mouse IgG1, cat. 12-4714)

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