b-Catenin (Total/Phospho) InstantOne ELISA **

产品名称：b-Catenin (Total/Phospho) InstantOne™ ELISA
产品货号：eBioscience 85-86143-11
产品规格：96 tests
beta-Catenin (Total/Phospho) InstantOne™ ELISA
Also known as: CTNNB1
RUO: For Research Use Only. Not for use in diagnostic procedures.
Attention: The Total/Phospho InstantOne ELISAs contain reagents for a total of 96 wells (24 wells total/72 wells phospho). Please contact Technical Service for a lot specific COA.
SKU# 85-86143
Cat. No. Size
85-86143-11  96 tests 
Description: The InstantOne™ ELISA is specifically engineered for accurate measurement of total and phosphorylated human, mouse, and rat beta-Catenin (Ser45) in cell lysates. The InstantOne™ ELISA kit allows for fast analysis of samples in approximately one hour. All reagents used in a traditional sandwich ELISA are added in solution to a plate followed by a wash step and detection with the TMB colorimetric substrate.
beta-Catenin is a component of the WNT/Frizzled pathway. Beta-Catenin associates with the cytoplasmic domain of E-Cadherin, a protein that helps govern cell-cell adhesion, as well as the tumor suppressor adenomatous polypopsis coli (APC). GSK3 phosphorylates both beta-Catenin and APC, thereby marking them for degradation. Wnt binding to the Frizzled receptor induces GSK3 phosphorylation, which leads to inhibition of its kinase activity and subsequent reduction in ß-Catenin phosphorylation and degradation. As such, beta-Catenin translocates into the nucleus and functions as a co-activator of the TCF/LEF transcription factor family, which plays key roles in regulating genes involved in development and cancer progression.

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