Affinity Purified anti-human Caspase-8 100 ug原装**

产品名称：Affinity Purified anti-human Caspase-8 100 ug
产品货号：eBioscience 14-9934-82
产品规格：100 ug
Anti-Human Caspase 8 Purified
Also known as: Caspase8, CASP8
Clone: 1H10
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 14-9934
Cat. No. Size
14-9934-80  25 ug 
14-9934-82  100 ug 
Description: The monoclonal antibody 1H10 recognizes human Caspase-8 also known as FLICE and MACH, a member of the cysteine-requiring aspartate protease family. Caspase-8 is an upstream caspase responsible for Fas and TNF-α mediated apoptosis. After activation of the Fas or TNF receptors by their ligands, the adaptor molecule FADD binds to the receptor and recruits caspase-8 to the membrane. The formation of this complex induces the cleavage and activation of caspase-8. The active form of caspase-8, made of a heterotetramer of p18 and p10, is released in the cytoplasm and activates downstream apoptotic proteases (caspase-3, -4, -6, -7, -9 and -10). Several (> 8) isoforms have been identified: 3 different pro-forms called Caspase-8a (55kDA), Caspase-8b (53kDa), and Caspase-8L which is procaspase-8 with an additional N-terminal extension of 59 aa.
The 1H10 antibody recognizes the p55 and p53 proforms in addition to the p43 and p18 cleaved forms. Under reducing conditions, an additional band (possibly non-specific) around 35kDa may be present. Under nonreducing conditions, this band is absent.

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