anti-mouse Toll-like receptor 4/MD-2 Purified MTS510 原装**

产品名称：anti-mouse Toll-like receptor 4/MD-2 Purified MTS510 100 ug
产品货号：eBioscience 14-9924-82
产品规格：100 ug
Anti-Mouse TLR4/MD-2 Complex Purified
Also known as: TLR4/ MD-2, TLR-4/ MD2, toll-like receptor MD2
Clone: MTS510
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 14-9924
Cat. No. Size
14-9924-81  50 ug 
14-9924-82  100 ug 
Description: The MTS510 monoclonal antibody reacts with the mouse Toll-like receptor 4 (TLR4)/MD-2 complex. At least ten members of the Toll family have been identified. This family of type I transmembrane proteins is characterized by an extracellular domain with leucine-rich repeats and a cytoplasmic domain with homology to the type I IL-1 receptor. Two of these receptors, TLR2 and TLR4, are pattern recognition receptors and signaling molecules in response to bacterial lipoproteins and have been implicated in innate immunity and inflammation. TLR4 physically associates with MD-2, and together with CD14, this complex is responsible for LPS recognition and signaling. In the mouse, TLR4 is expressed by thioglycolate-elicited peritoneal macrophages. Incubation of peritoneal macrophages with LPS results in down regulation of surface TLR4/MD-2. The TLR4 gene is defective in C3H/HeJ and C57BL/10ScCr mice, both of which have been well characterized as hyporesponders to LPS.
The MTS510 monoclonal antibody co-immunoprecipitates MD-2 (~30 kDa) and TLR4 (~100 kDa), and preferentially reacts with TLR4 that is associated with MD-2. In comparison, binding of the UT41 monoclonal antibody occurs with and without formation of the TLR4/MD-2 complex . Please contact eBioscience Technical Support for further information.

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