Anti-Human SLAM-associated protein Purified (10C4-SAP) **

产品名称：Anti-Human SLAM-associated protein Purified (10C4-SAP) 100 ug
产品货号：eBioscience 14-9888-82
产品规格：100 ug
Anti-Human SAP (SLAM-Associated Protein) Purified
Also known as: T-cell signal transduction molecule SAP, SH2D1A, DSHP, SAP
Clone: 10C4.2
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 14-9888
Cat. No. Size
14-9888-80  25 ug 
14-9888-82  100 ug 
Description: This 10C4.2 monoclonal antibody reacts with human SLAM-associated protein (SAP). Upon SLAM receptor ligation, this 16-kDa SH2 domain-containing adaptor protein recruits Fyn tyrosine kinase, which phosphorylates the receptor to activate downstream signaling events. SAP is expressed in T, NK, and NKT cells, as well as eosinophils and platelets. This protein has also been detected in B cells and tumor cell lines such as Jurkat and Raji. Studies demonstrate that SAP expression in T follicular helper cells is required for germinal center formation. Moreover, this protein is involved in NKT cell development, Th1/Th2 differentiation, and controlling NK cytotoxicity. The role of SAP in B cells, however, is currently under investigation. Finally, deletion of the gene encoding SAP, SH2D1A, results in X-linked lymphoproliferative disease in humans.

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