anti-human Fn14/TWEAK Receptor (CD266) Purified ITEM-1 **

产品名称：anti-human Fn14/TWEAK Receptor (CD266) Purified ITEM-1 100 ug
产品货号：eBioscience 14-9019-82
产品规格：100 ug
Anti-Human CD266 (TWEAK Receptor) Purified
Also known as: TNFRSF12A , TWEAKR, Fibroblast growth factor-inducible 14, Fn14
Clone: ITEM-1
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 14-9019
Cat. No. Size
14-9019-80  25 ug 
14-9019-82  100 ug 
Description: The ITEM-1 mAb reacts with human TWEAK Receptor/Fn14 (fibroblast growth factor-inducible 14 kDa protein). Fn14 is distantly related to the TNFR family, containing one cysteine-rich domain in the extracellular region and a TNFR-associated factor binding domain but does not contain a death domain (DD) cytoplasmic region. Fn14 plays a role in TWEAK-induced endothelial cell migration, proliferation, and angiogenesis. TWEAK-induced cell death via Fn14 includes both apoptosis and necrosis and can be blocked by an anti-TWEAK antibody, CARL-1. Fn14 is expressed on HUVEC and in some cancer tissues but not on freshly isolated PBMCs. Fn14 mRNA expression has been identified during liver regeneration.

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