Human CCL19 (MIP-3) Recombinant Protein **

产品名称：Human CCL19 (MIP-3)  Recombinant Protein 25 ug
产品货号：eBioscience 14-8997-80
产品规格：25 ug
Human CCL19 (MIP-3 beta) Recombinant Protein
Also known as: C-C Motif Chemokine 19
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 14-8997
Cat. No. Size
14-8997-62  5 ug 
14-8997-80  25 ug 
Description: CCL19, also known as MIP-3 beta (Macrophage Inflammatory Protein 3 beta), is a member of the CC- subfamily of chemokines. It is most closely related to CCL21, with which it shares 32% amino acid sequence homology. CCL19 and CCL21 are expressed mainly by stromal cells in the T cell-rich zones of lymph nodes. They are critical mediators of the homeostatic trafficking of naïve T cells and activated dendritic cells into the secondary lymphoid organs. CCL19 and CCL21 also play a role in T cell priming and activation, as well as the recruitment of lymphocytes to inflamed tissue. Both proteins signal via the G protein-coupled receptor, CCR7, which is expressed on T cells and mature dendritic cells. Although CCL19 and CCL21 both exhibit the same affinity for CCR7, only the binding of CCL19 results in the desensitization and internalization of the receptor.

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