Recombinant human TSLP, **

产品名称：Recombinant human TSLP, 25 ug
产品货号：eBioscience 14-8497-80
产品规格：25 ug
Human TSLP Recombinant Protein
Also known as: Thymic Stromal-Derived Lymphopoietin
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 14-8497
Cat. No. Size
14-8497-62  5 ug 
14-8497-80  25 ug 
Description: Thymic Stromal Lymphopoietin (TSLP) is a member of the B cell-stimulating factor family. This hemopoietic cytokine was identified from the conditioned medium of a mouse thymic stromal cell line that promoted B-cell development. TSLP is expressed in thymus, spleen, kidney, lung and bone marrow. The bioactivity of TSLP overlaps with that of IL-7, playing a key role in B cell development, as well as stimulating the growth of thymocytes and T cells. Whereas IL-7 facilitates the development of B220+/IgM- pre-B cells, TSLP promotes the development B220+/IgM+ B cells in the mouse. In addition, TSLP stimulates monocytes to produce the T cell-attracting chemokines TARC (CCL17) and MDC (CCL22). TSLP also activates dendritic cell-primed CD4 T cells to produce Th2 cytokines (e.g. IL-4, IL-5, IL-13, and TNFα). TSLP binds to a heterodimeric receptor complex consisting of the IL-7R alpha chain (IL-7Rα) and the TSLP-specific chain (TSLPR) to induce STAT3 and STAT5 phosphorylation. Mouse TSLP shares approximately 43% amino acid sequence identity with human TSLP. Recombinant human TSLP is a 15.0 kDa protein consisting of 121 amino acid residues.

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