anti-human CMKLR1 Purified BZ332 **

产品名称：anti-human CMKLR1 (serpentine chemokine-like receptor 1, DC-expressed serpentine receptor, pDC-marker, plasmacytoid DC-marker) Purified BZ332 100 ug
产品货号：eBioscience 14-7581-82
产品规格：100 ug
Anti-Human CMKLR1 Purified
Also known as: serpentine chemokine-like receptor 1
Clone: BZ332
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 14-7581
Cat. No. Size
14-7581-80  25 ug 
14-7581-82  100 ug 
Description: The BZ332 antibody reacts with human chemokine-like receptor 1, CMKLR1. CMKLR1 (also known as ChemR23 or DEZ), is a recently-described serpentine chemoattractant receptor. CMKLR1 has been shown to be expressed by dendritic cells (DC) generated in vitro from monocytes, and to mediate their migration to the proteolytically regulated chemoattractant chemerin. CMKLR1 is expressed by circulating DCs in human blood. Importantly, it is selectively expressed by immature plasmacytoid DCs, but not myeloid DCs, thus enabling discrimination between these two dendritic cell lineages. While CMKLR1 is expressed by circulating pDCs in human blood, mDCs, as well as lymphocytes, monocytes, neutrophils, and eosinophils are negative. Human serum contains a chemoattractant for CMKLR1 which is identical with chemerin; this activity is triggered during blood coagulation, suggesting a mechanism for attraction of pDCs to sites of tissue damage and bleeding. Expression of CMKLR1 and migration to locally activated chemerin may allow the rapid and differential recruitment of pDCs in vivo. Unlike mDCs, circulating pDCs do not respond to inflammatory chemokines.

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