Human RORg (clone 4F3-3G8-2), **

产品名称：Human RORg (clone 4F3-3G8-2), 100 ug
产品货号：eBioscience 14-6989-82
产品规格：100 ug
Anti-Human ROR gamma Purified
Also known as: RORgamma, RORg, RORg(t), Retinoid-Related Orphan Receptor gamma, RORc
Clone: 4F3-3C8-2B7
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 14-6989
Cat. No. Size
14-6989-80  25 ug 
14-6989-82  100 ug 
Description: The 4F3-3G8-2B7 monoclonal antibody reacts with the DNA binding domain of human and mouse RORγ protein. RORγ is a member of the retinoic acid-related orphan receptor (ROR) family, which also includes RORalpha and RORbeta. ROR family proteins are ligand-dependent transcription factors that play roles in multiple physiological processes. RORγ is expressed in several tissues, including liver, lung, muscle, heart and kidney. Furthermore, it was discovered that alternative transcription results in the expression of an isoform, RORγt, that is expressed exclusively in cells of the lymphoid compartment, namely CD4+CD8+ thymoyctes, Th17 cells of the periphery and lymphoid tissue inducer (Lti) cells of lymphoid organs.
The RORγt isoform differs from ROR by three unique amino acids at the amino terminus. Therefore, the 4F3-3G8-2 antibody will react with both the RORγ and RORγt isoforms. In addition our data suggests that 4F3-3C8-2B7 has greater sensitivity to human RORγ than to mouse RORγ. For detection of mouse RORγ, please use cat. 14-6981.

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