anti-mouse/human/rat beta-Catenin Purified Polyclonal

产品名称：anti-mouse/human/rat beta-Catenin Purified Polyclonal 50 ug
产品货号：eBioscience 14-6765-81
产品规格：50 ug
Anti-beta-Catenin Purified
Also known as: b-catenin, catenin b
Clone: Polyclonal
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 14-6765
Cat. No. Size
14-6765-63  10 ug 
14-6765-81  50 ug 
Description: The polyclonal antibody reacts with mouse, human, and rat beta-catenin; the antibody was raised against a peptide mapping to the carboxy terminal domain of human beta-catenin. The multifunctional beta-catenin protein was originally identified through its association with the cadherin class of cell adhesion proteins (1&2). It was later found to be an integral part of signal transduction pathways and the best studied is the Wnt/beta-catenin pathway (3). Wnt signaling inhibits the degradation of beta-catenin and as a result beta-catenin becomes transcriptionally active (3-5). The deregulation of Wnt signaling leads to the accumulation of beta-catenin, allowing it to become transcriptionally active for a number of genes. Many of these genes are associated with cancer, such as colorectal cancer and melanomas (3&4).

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