Anti-Apoptosis Inducing Factor (AIF) Purified **

产品名称：Anti-Apoptosis Inducing Factor (AIF) Purified (rabbit pAb)
产品货号：eBioscience 14-6050-82
产品规格：100 ug
Anti-Apoptosis Inducing Factor (AIF) Purified
Clone: Polyclonal
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 14-6050
Cat. No. Size
14-6050-82  100 ug 
Description: This rabbit polyclonal antibody reacts with human, mouse, and rat Apoptosis Inducing Factor (AIF). This 67-kDa flavoprotein is ubiquitously expressed and undergoes tissue-specific alternative splicing, resulting in the existence of five different isoforms. Moreover, AIF expression has been reported to be deregulated in cancer cells. AIF mediates caspase-independent programmed cell death in response to numerous stimuli, including hypoxia-ischemia, growth factor deprivation, excitotoxins, and glutamate receptor activation. Upon activation of apoptosis, AIF is released from the mitochondria and translocates into the nucleus to induce chromatin condensation and DNA fragmentation. Nuclear translocation of AIF can be inhibited by interaction with members of the heat shock protein 70 family.

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