Sigma C3662 Cyclosporin A≥95% (HPLC),Cyclosporine,环胞霉素A,CsA, Cs-A, CY-A, Sandim

Synonym:

Antibiotic S 7481F1, Cyclosporine

CAS Number:

59865-13-3

Linear Formula:

C₆₂H₁₁₁N₁₁O₁₂

Molecular Weight:

1202.61

Beilstein Registry Number:

3647785

MDL number:

MFCD00274558

PubChem Substance ID:

24278028

Biochem/physiol Actions

A fungal metabolite possessing potent immunosuppressive properties. It inhibits the T-cell receptor signal transduction pathway via the formation of cyclosporin A−cyclophilin complex that inhibits calcineurin (protein phosphatase 2B). Inhibits nitric oxide synthesis induced by interleukin 1α, lipopolysaccharides and TNFα. Can block cytochrome c release from mitochondria.

biological source

from Tolypocladium inflatum

assay

≥95% (HPLC)

form

solid

color

white

solubility

dichloromethane: 10 mg/mL

ethanol: 10 mg/mL

DMSO: 50 mg/mL

chloroform: 6 mg/mL

H₂O: insoluble

Gene Information

human ... PPP3CA(5530), PPP3CB(5532), PPP3CC(5533), PPP3R1(5534), PPP3R2(5535)

storage temp.

2-8°C

Personal Protective Equipment

Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

Hazard Codes

T

Risk Statements

45-60-22

Safety Statements

53-45

WGK Germany

3

RTECS

GZ4120000

reference

Donjerkovic, et al., Regulation of p27Kip1 accumulation in murine B-lymphoma cells: role of c-Myc and calcium. Cell. Growth Differ. 10, 695-704, (1999)

Mordvinov, et al., A human T-cell line with inducible production of interleukins 5 and 4. A model for studies of gene expression. J. Immunol. Methods 228, 163-168, (1999)

Zaidan, et al., Cyclosporin A-sensitive changes in mitochondrial glutathione are an early response to intrastiatal NMDA or forebrain ischemia in rats. J. Neurochem. 73, 2214-2217, (1999)

Pritchard, D.E., et al., Cyclosporin A inhibits chromium(VI)-induced apoptosis and mitochondrial cytochrome c release and restores clonogenic survival in CHO cells. Carcinogenesis 21, 2027-2033, (2000)

Merck

Merck 13,2781

品名

产地

货号

规格

单价

备注

环胞霉素A/环孢霉素A  CYCLOSPORIN A

SIGMA

C3662

5MG

询价