Pepstatin,Pepstatin A,抑肽素,胃蛋白酶抑制剂,

CAS Number:

26305-03-3

Linear Formula:

C₃₄H₆₃N₅O₉

Molecular Weight:

685.89

Beilstein Registry Number:

2201362

EC Number:

247-600-0

MDL number:

MFCD00060740

PubChem Substance ID:

24898519

Preparation Note

Pepstatin can be dissolved at 1 mg/ml in 10% (v/v) acetic acid in methanol (9:1 methanol:acetic acid). The inclusion of acetic acid may be necessary to dissolve this peptide in methanol or DMSO. It has been dissolved at 1 to 2 mg/ml in ethanol, but heat may be required for complete dissolution. Solutions of Pepstatin A can be heated as high as 60 °C without any decomposition of the peptide.
Stock solutions at 1 mg/ml are stable at least a week at 4 °C. A 1 mM solution in methanol or DMSO is stable for months at -20 °C. If solutions become darker yellow, the reagent is hydrolyzing.
A working concentration of 1 μM is stable for at least one day at room temperature.

Biochem/physiol Actions

Pepstatin A is an inhibitor of acid proteases (aspartyl peptidases). It forms a 1:1 complex with proteases such as pepsin, renin, cathepsin D, bovine chymosin, and protease B (Aspergillus niger). The inhibitor is highly selective and does not inhibit thiol proteases, neutral proteases, or serine proteases. Solubilized γ-secretase and retroviral protease are also inhibited by Pepstatin A. It has been used to characterize proteases from several sources.

biological source

microbial

assay

≥75% (HPLC)

mp

233 °C (dec.)(lit.)

storage temp.

2-8°C

Personal Protective Equipment

Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter

Safety Statements

22-24/25

WGK Germany

2

RTECS

SC6155000

品名

产地

货号

规格

单价

备注

Pepstatin胃蛋白酶抑制剂

Sigma

P4265

5mg

询价

现货