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SFTPD Rabbit pAb（肺表面活性蛋白D抗体）

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产品名称: SFTPD Rabbit pAb（肺表面活性蛋白D抗体）
产品型号: yb-1583R
产品展商: CASMASCI
产品文档: 无相关文档

简单介绍

SFTPD Rabbit pAb（肺表面活性蛋白D抗体）


SFTPD Rabbit pAb（肺表面活性蛋白D抗体）  的详细介绍
英文名称SFTPD Rabbit pAb
中文名称肺表面活性蛋白D抗体
别    名SFTPD surfactant protein D; pulmonary surfactant-associated glycoprotein D; COLEC 7; COLEC7; Collectin7; PSP D; PSPD; Pulmonary surfactant apoprotein; Pulmonary surfactant associated protein D; SFTP 4; SFTP4; SFTPD; SP D; Surfactant associated protein pulmonary 4; Surfactant pulmonary associated protein D; SFTPD_HUMAN; Pulmonary surfactant-associated protein D; PSP-D; SP-D; Collectin-7; Lung surfactant protein D.  

克隆类型  Polyclonal
交叉反应  Human (predicted: Mouse,Rat)
产品应用  WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,Flow-Cyt=2ug/Test
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理论分子量 41 kDa
检测分子量
细胞定位分泌型蛋白 
性    状   Liquid
浓    度  1mg/ml
免 疫 原  KLH conjugated synthetic peptide derived from human SP-D: 301-375/375 
亚    型   IgG
纯化方法  affinity purified by Protein A
缓 冲 液  0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存条件  Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMedPubMed

产品介绍

Surfactant protein D contributes to the lung's defense against inhaled microorganisms. It's a calcium ion dependent carbohydrate binding protein and is structurally similar to other C type mammalian lectins, such as conglutinin and SPA. It has a molecular size of approximately 37-43kDa in its reduced state, 620kDa in non dissociating conditions. Surfactant protein D enhances the production of oxygen radicals by rat alveolar macrophages and regulates some actions of SPA, which is the most abundant surfactant protein. Surfactant protein D is synthesized and secreted by alveolar epithelial type II cells.


Function:
Contributes to the lung's defense against inhaled microorganisms. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties.

Subunit:
Oligomeric complex of 4 set of homotrimers.

Subcellular Location:
Secreted, extracellular space, extracellular matrix. Secreted, extracellular space, surface film.

Post-translational modifications:
The N-terminus is blocked.
Hydroxylation on proline residues within the sequence motif, GXPG, is most likely to be 4-hydroxy as this fits the requirement for 4-hydroxylation in vertebrates.

Similarity:
Belongs to the SFTPD family.
Contains 1 C-type lectin domain.
Contains 1 collagen-like domain.

SWISS:
P35247

Gene ID:
6441
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